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of pancreatitis. In vivo studies indicated evidence of a low propensity for causing smashburger buy one get one free coupon drug interactions with substrates of CYP3A4, CYP2C9, CYP2C8, P-gp and organic cationic transporter (OCT). Janumet is contraindicated in patients with an estimated glomerular filtration rate (eGFR) below 30 mL/min/1.73 m2 see Contraindications (4) and Warnings and Precautions (5.1). Serious side effects have happened in people taking Janumet or the individual medicines in Janumet.

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Renal Impairment No dose adjustment is recommended for patients with renal impairment see Clinical Pharmacology (12.3). However, the studies were not designed to definitely establish the risk of use of metformin during lactation because of small sample size and limited adverse event data collected in infants. Use caution in a patient with a history of angioedema with another DPP-4 inhibitor because it is unknown whether such patients will be predisposed to angioedema with Janumet. Race No dose adjustment is necessary based on race. If a hypersensitivity reaction is suspected, discontinue Janumet, assess for other potential causes for the event, and institute alternative treatment for diabetes. After initiation of Janumet, patients should be observed carefully for signs and symptoms of pancreatitis.



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Tradjenta official prescribing information for healthcare professionals.
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Janumet official prescribing information for healthcare professionals.


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